The insulin-like growth factor 1 (IGF1) signaling pathway has emerged as a major regulator of the aging process, from rodents to humans. However, given the pleiotropic actions of IGF1, its role in the aging brain remains complex and controversial.
Similarly, is IGF-1 GOOD OR BAD?
People may also misuse or abuse IGF–1. The side effects of IGF–1 may be similar to those of other growth hormones. These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF–1 can cause your blood glucose levels to drop.
Furthermore, what does high IGF-1 level mean?
Elevated IGF–1 and GH may indicate acromegaly in adults. Increased levels of GH and IGF–1 are normal during puberty and pregnancy; during the latter, serum IGF–1 increases on average almost 2-fold. Otherwise, increased levels are most frequently due to pituitary tumors (usually benign).
Does IGF-1 Really Work?
While IGF–1 could help athletes in theory, said Dr. Alan Rogol, a vice president of the Endocrine Society, there are no scientific studies with humans to show the expected effects actually occur. In animals, he said, if IGF–1 is injected into the body, muscles grow.
How can I lower my IGF-1?
The combination of a low-fat diet and exercise program is known to reduce IGF levels. Barnard et al. [13, 14] showed a decrease in the serum concentration of IGF-I and an increase in IGFBP-1 with the implementation of a low-fat diet and exercise program.
Does IGF-1 cause weight gain?
Impact. Although weight gain was not consistent with increases in IGF-I levels among postmenopausal women in this report, avoidance of weight gain as a strategy to reduce cancer risk may be recommend.
Does IGF-1 build muscle?
In addition to a direct anabolic effect on skeletal muscle—for example, the production of more protein—IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells). Results of animal studies suggest that this process is obligatory for muscle hypertrophy to proceed.
Which is better HGH or IGF-1?
HGH is generally considered to employ anti-insulin actions, whereas IGF–1 has insulin-like properties. By maintaining relatively low levels of IGF–1 and synergy between HGH and IGF–1 throughout your patients’ adult life, they may be able to live a healthy lifestyle and experience optimal aging.
What foods are high in IGF?
The following foods/nutrients increased IGF-1 levels in humans:
- protein derived from milk, fish and poultry, but not red meat (Giovannucci and coworkers, 2003)
- protein derived from red meat, fish, seafood and zinc (Larsson and coworkers, 2005)
Does testosterone increase IGF-1?
Testosterone significantly increased thymidine incorporation and the production of IGF–1 and IGF-BP (p < 0.05 vs control). However, T significantly decreased the cell surface binding of IGF–1 (p < 0.0001 vs control).
What should my IGF-1 levels be?
Low IGF–1 is considered by most to be between 84–100 µ/l and numerous studies recommend that raising IGF–1 to high normal range reverses Chronic Medical Diseases (CMD), improves bone mineral density (BMD), and fibromyalgia.
How do you treat high IGF-1?
To help lower your GH and IGF–1 levels, treatment options typically include surgery or radiation to remove or reduce the size of the tumor that is causing your symptoms, and medication to help normalize your hormone levels.
What causes high IGF levels?
Levels of IGF–1 that are higher or lower than normal may also be caused by: Hypothyroidism, or low thyroid hormone levels. Liver disease. Uncontrolled diabetes mellitus.
What is a normal IGF-1 result?
The median serum IGF-I level was 374.1 ng/ml at the age of 18. The serum IGF-I level decreased to 180.1 ng/ml at the age of 35–39, which is 48.1% of that at age 18, and further decreased to 92.7 ng/ml at ages older than 70, which is approximately 24.8% of that at age 18.