Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic pathways. FGF21 is expressed in several metabolically active organs and interacts with different tissues.
Moreover, what is the function of FGF21?
FGF21 is a secreted protein that has been shown to act as a metabolic regulator that plays a role in controlling glucose homeostasis, insulin sensitivity, and ketogenesis (Badman et al., 2007; Galman et al., 2008).
Keeping this in view, is FGF 21 a hormone?
Fibroblast growth factor 21 (FGF21) is an endocrine hormone that is primarily expressed in the liver and exerts beneficial effects on obesity and related metabolic diseases.
Who discovered FGF21?
The mouse and human FGF21 genes were originally cloned by Dr. Nobuyuki Itoh’s group via a PCR approach utilizing FGF-derived degenerative primers, and the highest expression of FGF21 transcript was found in mouse liver and thymus [7].
What is Irisin found in?
Irisin is not only present in skeletal muscle, but also in the cardiac muscle, brain, and skin and in smaller amounts in the liver, pancreas, and other tissues (Aydin et al., 2014).
What is FGFR1 gene?
The FGFR1 gene is involved in a type of blood cancer called 8p11 myeloproliferative syndrome. This condition is characterized by an increased number of white blood cells (myeloproliferative disorder) and the development of lymphoma, a blood-related cancer that causes tumor formation in the lymph nodes.
What is leptin made of?
Leptin (from the Greek word leptos, meaning “thin”) is derived from the lep gene, located on chromosome 7, which transcribes a 167 amino acid peptide with a molecular weight of 16kD.