Dr. David Sinclair’s main research interest is the epigenetics of aging, with a focus on epigenetic reprogramming of aging (e.g. reversing aging via Yamanaka factors), NAD+ metabolism and sirtuins, and NAD+ precursors like NR and NMN.
Subsequently, is Dr Sinclair legit?
Is David Sinclair Legit? Yes, David Sinclair is legit. He holds a PhD from the University of New South Wales (Sydney, Australia) and is a Full Professor at Harvard where is working since 1999. He is author of hundreds of peer-reviewed scientific publications.
In this way, what is David Sinclair diet?
David and Matthew go over three primary ways of fasting: the fasting-mimicking diet, intermittent fasting, and time-restricted feeding. The fasting-mimicking diet involves lowering mTOR activity by reducing the consumption of branched-chain amino acids. For this diet, the time window for eating isn’t as rigorous.
Which is better resveratrol or pterostilbene?
Overall, pterostilbene performs better in membrane permeability and metabolic stability than resveratrol. This increases the bioavailability, and enhances the pharmacokinetic profile and pharmacological activities of pterostilbene.
What are the side effects of NMN?
Table 2
| Affected Organs and Conditions 2 | Observed Effects |
|---|---|
| Adverse Effects | |
| Minor effects | Frontal dull headaches, nausea, headache, dizziness |
| Pancreatic ?-cell/plasma | Decreased insulin sensitivity, increased oxidative stress (H2O2) |
| Liver | Parenchymal-cell injury, portal fibrosis and cholestasis, liver injury |
Is NMN worth taking?
In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more.
Why does Sinclair take metformin?
Metformin has become a popular anti-aging drug in part because of the work of Harvard biologist David Sinclair, who uses metformin to lengthen lifespan. A recent article in Internal Medicine Alert indicated hospitalized patients on metformin were at a lower risk of mortality.
Does resveratrol Make You Look Younger?
More specifically, resveratrol may support the function and structure of the skin by reducing the appearance of fine lines and wrinkles, and improving skin tone by reducing the impact of free-radical damage to the skin.
What kind of vitamins does Joe Rogan take?
In a 2014 vlog, Joe Rogan showed off his supplement cupboard and said he was taking a Vitamin B complex and Vitamin B3 (niacin). As recently as March 2019, he confirmed that he still supplements with Vitamin B daily.
What NMN does David Sinclair?
Nicotinamide Mononucleotide (NMN)
In his book ‘Lifespan’, David Sinclair mentions that he takes 1 gram of NMN. This is an obvious choice because recent research has been pointing towards the benefits of taking NAD+ precursors.
How much metformin does Dr Sinclair take?
Dr. Sinclair takes 1000mg of Metformin daily—and has no plans to stop this life—extending ritual. He has gone on record as stating that, “The science [behind Metformin] is convincing, and we are taking these molecules to forestall old age” (more here).